New BNF maximum recommended dose for haloperidol
نویسندگان
چکیده
منابع مشابه
Predictive Models for Maximum Recommended Therapeutic Dose of Antiretroviral Drugs
A novel method for predicting maximum recommended therapeutic dose (MRTD) is presented using quantitative structure property relationships (QSPRs) and artificial neural networks (ANNs). MRTD data of 31 structurally diverse Antiretroviral drugs (ARVs) were collected from FDA MRTD Database or package inserts. Molecular property descriptors of each compound, that is, molecular mass, aqueous solubi...
متن کاملWhich dose of haloperidol?
Although haloperidol (HAL)has been available as an antipsychotic for over 30 years, controversy still surrounds the appropriate dose in the treatment of psychosis and in particular, schizo phrenia. In practice, high dose HAL (greater than 20 mg/day) continues to be prescribed, despite good reason for not doing so: the incidence of extrapyramidal side-effects (EPSE) is known to be dose-related; ...
متن کاملUse of iodine for water disinfection: iodine toxicity and maximum recommended dose.
Iodine is an effective, simple, and cost-efficient means of water disinfection for people who vacation, travel, or work in areas where municipal water treatment is not reliable. However, there is considerable controversy about the maximum safe iodine dose and duration of use when iodine is ingested in excess of the recommended daily dietary amount. The major health effect of concern with excess...
متن کاملLocally weighted learning methods for predicting dose-dependent toxicity with application to the human maximum recommended daily dose.
Toxicological experiments in animals are carried out to determine the type and severity of any potential toxic effect associated with a new lead compound. The collected data are then used to extrapolate the effects on humans and determine initial dose regimens for clinical trials. The underlying assumption is that the severity of the toxic effects in animals is correlated with that in humans. H...
متن کاملEstimation of Maximum Recommended Therapeutic Dose Using Predicted Promiscuity and Potency
We report a simple model that predicts the maximum recommended therapeutic dose (MRTD) of small molecule drugs based on an assessment of likely protein-drug interactions. Previously, we reported methods for computational estimation of drug promiscuity and potency. We used these concepts to build a linear model derived from 238 small molecular drugs to predict MRTD. We applied this model success...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Psychiatric Bulletin
سال: 2001
ISSN: 0955-6036,1472-1473
DOI: 10.1192/pb.25.3.117-b